Effects of THC-O

Medically reviewed by Alexander Tabibi, MD
August 4, 2022
Effect Cannabis THC-O
Effect Cannabis THC-O

In this article we review the effects of THC-O. Currently, there is almost no reliable data or research on this cannabinoid. At the same time, there are numerous reviews from people who’ve already tried it. It is suggested that the substance could help manage pain, boost appetite, and reduce anxiety. High doses of it could prove incapacitating. Moreover, some users claim that its effects are similar to those experienced from low levels of mescaline.

Although the exact mechanism of action is not yet fully understood, it is known that THC-O acetate binds to the CB1 and CB2 receptors in the body. This causes a release of dopamine in the brain, which results in psychoactive effects. 

What are the effects of THC-O? The psychoactive effects of THC-O acetate are similar to those produced by tetrahydrocannabinol (THC). A low dose of THC-O may induce a mildly euphoric high which similar to delta-8 THC. A moderate dose may induce a more psychedelic experience. Finally, a high dose can leave you cognitively and physically incapacitated for some period of time.

But some psychoactive effects make it suitable for use as an antidepressant and appetite stimulant. It is also beneficial for managing pain and anxiety. The psychoactive THC O acetate effects are stronger than those produced by THC because it is more potent than its parent compound. The exact potency of this cannabinoid has not yet been determined; however, it is believed to be around 2% to 5% that of THC’s potency in animal models (i.e., 0.2–0.5 mg/kg).

Considering this, it can have stronger side effects. These side effects include impaired coordination, fatigue, dizziness, and sedation. It can also cause feelings of paranoia and anxiety in some people.

The psychoactive effects of THC-O acetate may last for up to four hours after administration. However, the duration of these effects depends on the dose taken by the user. Effects usually begin within 15–45 minutes after administration and peak within one hour before gradually subsiding over a period of two to three hours.

Manage Pain with THC-O

Another advantage of THC-O acetate can be used to treat pain, nausea, and other conditions. However, this synthetic form of THC does have some side effects such as dizziness, drowsiness, and dry mouth.

Some people do find it helpful in managing pain. For example, a person who has chronic pain may be able to use low levels of THC-O acetate to help with pain without experiencing a trip. If possible, it’s best to talk to a doctor before using this substance, as it may not be safe for every condition.

The main disadvantage of using THC-O acetate is that it does not work for everyone. This means that people who do not respond well to this substance may not have even proper THC-O gummies effects, so there’s a need to try other alternatives before they are able to find a treatment that works for them. Another disadvantage of using this substance is the fact that it can have different effects depending on how much you use or how often you use it compared with other forms of cannabis such as marijuana or hash oil. For this reason, many people who need cannabis for treating pain should start with a lower dose.

Effects of THC-O on Boosting Appetite

Some people also report that among the THC-O effects, they’ve noticed the ability to help with appetite. This is a benefit that is shared by other compounds, such as THC, CBD, and CBN. However, it’s not clear if the effects of this substance are different from those of other cannabinoids.

It’s best to talk to a doctor before using THC-O acetate for any condition. The dosage will also depend on the condition someone has and their weight. If you want to try it out for yourself without seeing a doctor, start with small doses and slowly increase the dosage over time. Don’t take high doses unless your doctor recommends it for your specific condition.

THC-O Can Probably Reduce Anxiety

There is a possibility that THC-O acetate can help reduce anxiety, but there’s no research on this yet. It’s more likely that this cannabinoid will help people with anxiety who have a condition related to pain, such as post-traumatic stress disorder.

In this case, a low dose of this substance might help a person relax without causing a trip. It’s best to discuss the desire to take this substance with a doctor, but anxiety may respond well to this cannabinoid.


There’s not much research on THC-O acetate, but what’s available suggests it could help with pain, boost appetite, and reduce anxiety.

There’s also a possibility that it could help with anxiety. If you have a condition that’s related to pain, this oil may be effective in managing pain without causing a trip.

If you have anxiety, it’s best to discuss the possibility of taking this substance with a doctor, but it may help with anxiety without getting you really high.

Please note: Weed.com does not make any medical claims regarding the efficacy of cannabis or cannabinoids.