Can Marijuana Help with Alzheimer’s?
Alzheimer’s Studies and Medical Marijuana
Studies have shown progress in the effects of medical marijuana and the treatment and management of Alzheimer’s disease.
A preclinical research released in the Journal of Alzheimer’s Disease found that extremely low dosages of tetrahydrocannabinol (THC), a chemical located in cannabis, can slow down the production of beta-amyloid healthy proteins, believed to be a trademark characteristic as well as key contributor to the development of Alzheimer’s.
The study, published in 2014, supports the effectiveness of THC in blocking the growth of poisonous amyloid plagues.
Co-author of the research, Neel Nabar, cautions against drawing conclusions from their research saying:
“It’s crucial to keep in mind that just because a drug may work does not indicate it can be safely used by any person. These searchings for may lead to the development of related substances that are safe, lawful, as well as useful in the treatment of Alzheimer’s illness.”
Another study from the Salk Institute in La Jolla, California has actually likewise discovered that tetrahydrocannabinol and also other substances located in cannabis may reduce the quantity of beta amyloid in the brain. Beta amyloid is a hallmark quality of Alzheimer’s and is frequently believed to create the neurodegenerative illness.
While the findings are early, researchers are optimistic. David Schubert, professor at the Salk Institute as well as senior writer on the research claims,
“Although other studies have actually offered evidence that cannabinoids might be neuroprotective versus the symptoms of Alzheimer’s, our company believe our research is the very first to demonstrate that cannabinoids influence both inflammation and also amyloid beta buildup in afferent neuron.”
In the research, scientists discovered that by exposing beta amyloid proteins to THC, it reduced the degrees of beta amyloid, quit the inflammatory response from the nerve cells caused by beta amyloid and also permitted the nerve markets to make it through. Antonio Currais, a postdoctoral scientist and also initial author on the paper noted:
“Inflammation within the brain is a significant element of the damage related to Alzheimer’s condition, but it has actually constantly been assumed that this response was originating from immune-like cells in the mind, not the nerve cells themselves. When we were able to identify the molecular basis of the inflammatory feedback to amyloid beta, it became clear that THC-like compounds that the afferent neuron make themselves might be associated with protecting the cells from passing away.”
Scientists caution that their studies were conducted in a lab and further research needs to be done in a clinical trials prior to any conclusive evidence can be generated. Additional studies are ongoing and many can be found here.
Alzheimer’s and dementia have similarities in the presentation, in that they both decrease the cognitive abilities and increase the levels of disorientation and confusion in those who suffer from it. While the studies are ongoing and in some cases, inconclusive in how and to what degree cannabis and THC help in the treatment or management, one thing is sure, there’s hope.
Because it’s well known that cannabis helps with stress, anxiety, pain, and inflammation, it stands to reason that there is at least some benefit in using medical marijuana, because all of those contribute to the worsening of symptoms and compound the suffering. But science is starting to reveal there is more to it’s benefits than that. Some findings show that it doesn’t only reduce the presentation of the confusion, it actually reduces it at the source, by untangling the brain and removing some of the obstacles, to improve cognition overall.
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