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Anti-Anxiety Medication& Marijuana

When it involves mixing marijuana with various other anti-anxiety medicines, there are a few points to think about.

There hasn’t been much research studying the interaction of marijuana and these medications, yet based upon what is available, coupled with anecdotal reporting, we understand that the complicated mechanisms of action of some anti-anxiety medications, there are certain drugs that pose greater risks than others.


Anxiety Medications and Marijuana


SSRIs (serotonin reuptake inhibitors)– like Prozac, Paxil, Celexa, Zoloft, as well as Lexapro– are among the most common prescriptions for anxiety. Very few adverse interactions between marijuana and these SSRIs have actually been reported by patients.


This also appears to be few instance with NDRIs (norepinephrine and also dopamine reuptake inhibitors) like Wellbutrin, Aplenzin, as well as Forfivo.

Other Medications

Various other medicines require greater caution as cannabis could magnify negative effects such as increased heart rate as well as blood pressure. These higher-risk mixes include:

  • Sedatives (e.g., Xanax, Klonopin, Ambien).
  • Tricyclic antidepressants (e.g., imipramine/Tofranil, amitriptyline, doxepin, trimipramine/Surmontil).
  • MAOIs (e.g. tranylcypromine/Parnate, phenelzine/Nardil, isocarboxazid/Marplan).


Oftentimes medications are prescribed for symptoms of an underlying disease rather than the condition itself. This is an important consideration, especially when combining medications with medical marijuana, therefore there could be other changes or interactions you may notice that may or may not be related to the medication interactions. It’s always best to check with your healthcare provider and other experts to ensure you are being careful when adding to your regimen. It’s also good to speak with cannabis experts to select the right strain for your needs and interests.

You can overviews on Leafly for more details on just how marijuana may connect with antidepressants as well as various other medications.


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