Medically reviewed by Alexander Tabibi, MD
August 3, 2023

THC-O and Delta-9 are both cannabinoids found in the cannabis plant, each with distinct effects on the body and mind. While Delta-9 THC is the most well-known and widely researched cannabinoid, THC-O is a newer and less studied compound. In this article, we will compare and contrast THC-O and Delta-9 THC, providing an overview of their properties, effects, and potential benefits or risks.

This post is intended as information and for general knowledge only. It is not a substitute for medical advice, diagnosis, or treatment. It is recommended that you talk to a healthcare professional about this before introducing cannabinoids into your daily routine (especially if you have been diagnosed with any medical conditions or are under any medication). It is not recommended to drive or operate any machinery when using cannabis- or hemp-derived products. Use responsibly!

What is THC-O

THC-O, also known as THC acetate or THC-O acetate, is a synthetic cannabinoid derived from Delta-9 THC. It is created by synthesizing Delta-9 THC with acetic anhydride. The production process can be challenging and may involve risks associated with handling potentially hazardous chemicals.

Studies on THC-O’s medical potential are limited, but some researchers suggest that it may have therapeutic applications similar to Delta-9 THC. However, safety concerns and potential side effects need further exploration, as THC-O is a relatively new compound.

Currently, THC-O is subject to regulations in various jurisdictions due to its status as a controlled substance. The Drug Enforcement Administration (DEA) in the United States considers THC-O a controlled substance, which impacts its legality and accessibility.

What is Delta-9 THC

Delta-9 THC, often referred to simply as THC, is the primary psychoactive cannabinoid in the cannabis plant. It occurs naturally in the plant and is responsible for the characteristic “high” associated with marijuana use. Delta-9 THC interacts with the CB1 receptors in the endocannabinoid system, leading to various physiological and psychological effects.

The psychoactive effects of Delta-9 THC can include euphoria, relaxation, altered perception of time, and increased appetite. Additionally, it has shown promise in medical applications, such as pain relief, nausea reduction, and appetite stimulation, which has led to the development of THC-based medications.

Delta-9 THC is also a controlled substance under federal law in the United States, classified as a Schedule I drug due to its potential for abuse and lack of accepted medical use.

Differences between THC-O and Delta-9 THC

Potency-wise, THC-O is reported to be more potent than Delta-9 THC, requiring smaller doses to achieve similar effects. Users should exercise caution and start with lower doses when trying THC-O products, especially if they are accustomed to traditional Delta-9 THC products.

THC-O vs Delta-9

Regarding psychoactive effects, THC-O is said to produce a more intense and longer-lasting high compared to traditional Delta-9 THC. Users might experience a stronger euphoria and altered perception that lasts longer than when consuming standard THC.

The onset time and duration of effects can also differ between THC-O and Delta-9 THC. THC-O might take longer to take effect, but its effects may persist for an extended period compared to regular THC.

Research comparing the two cannabinoids is still in its early stages, and there is much more to learn about THC-O’s effects and safety compared to Delta-9 THC.

Similarities between THC-O and Delta-9 THC

Both THC-O and Delta-9 THC interact with the endocannabinoid system, primarily targeting the CB1 receptors. This interaction leads to similar psychoactive effects, such as euphoria, relaxation, and altered perception.

In terms of potential side effects, both cannabinoids share common adverse reactions reported by users, such as dry mouth, dizziness, and impaired cognitive function. However, more research is needed to fully understand the long-term impacts of THC-O compared to Delta-9 THC.

Legally, both THC-O and Delta-9 THC are subject to regulations in various jurisdictions. Due to their psychoactive properties and potential for abuse, they are classified as controlled substances under federal law in the United States.

Safety and Potential Risks

When it comes to safety, both THC-O and Delta-9 THC present short-term and long-term risks. Short-term risks include impaired judgment, increased heart rate, and anxiety, while long-term risks may involve cognitive deficits and potential addiction.

Comparing their safety profiles, more research is necessary to determine if THC-O poses additional risks compared to Delta-9 THC. Responsible use of any cannabis product is crucial, and users should be aware of the potential risks associated with both THC-O and Delta-9 THC.

Conclusion

In conclusion, THC-O and Delta-9 THC are two distinct cannabinoids with unique properties and effects. THC-O is a synthetic cannabinoid derived from Delta-9 THC, exhibiting more potent and long-lasting effects. Delta-9 THC, on the other hand, is the primary psychoactive compound naturally found in the cannabis plant and has been extensively studied for its medical potential.

Both THC-O and Delta-9 THC have their potential benefits and risks, and responsible use is essential for users considering trying any THC products, including edibles, gummies, vapes, or CBD oil derived from hemp.

As more research emerges, our understanding of THC-O and its effects will become clearer, but until then, users should approach their choices with informed decision-making, considering individual needs preferences, and local laws and regulations. Educating oneself about the products and using them responsibly will help ensure a safe and enjoyable experience with cannabis-derived compounds.